Gut function & microbiota


Ø iMOS® mannan oligosaccharide improves gut function & microbiota and helps to relieve the symptoms associated with intestinal inflammations (constipation & diarrhea)

Intestinal inflammations (IBS, IBD, etc.) are often associated with the destruction of intestinal structural integrity. iMOS® mannan oligosaccharide can improve gut integrity by increasing the length of the small intestinal villus, thickening the wall of the small intestine (Fig.1)



Ø iMOS® mannan oligosaccharide improves diabetes (type II) control

Type II diabetes is associated with obesity, and the patients are more likely to develop insulin resistance, a condition in which the cells no longer respond to the hormone and no longer absorb glucose. Metformin (MF) is the most widely used first-line drug for the treatment of type II diabetes. Experiments show that iMOS® mannan oligosaccharide is almost as effective as metformin in reducing plasma glucose (FBG), hemoglobin A1C (HbA1c), and insulin resistance (HOMA-IR), and a synergistic effect is observed when combining iMOS® mannan oligosaccharide and metformin. It also increases the abundance of Akkermansia muciniphila and Bifidobacterium pseudolongum, which is positively associated with the prevention and treatment of obesity and diabetes (type II) (Fig.1). 



Fig.1 iMOS® mannan oligosaccharide effectively improves the indicators of type II diabetes and also regulates the flora structure of the intestines.


Prebiotic mannan-oligosaccharides augment the hypoglycemic effects of metformin in correlation with modulating gut microbiota. Zheng et al.J. Agric. Food Chem. 2018 Apr. 27