Autoimmune diseases


Ø iMOS® mannan oligosaccharide supports the prevention and treatment of autoimmune diseases including allergy 

There are many forms of allergy, the most common of which are IgE mediated. Allergy develops when the immune system mounts a T helper 2 (TH2) cell-mediated responses against allergic epitopes. Common IgE-mediated allergies include those to food (peanuts, cow's milk, egg, soy, wheat, shellfish and fish) and pollen (Fig.2).



Fig.2 The most common allergens are divided into three types according to different sensitization pathways: inhalation, ingestion and contact.


iMOS® mannan oligosaccharide induces regulatory T cells (Treg) and increases the ratio of Treg cells to TH2 cells (Treg/TH2), which leads to the shift from the IgE to IgG4 isotype. IgG4 antibodies compete with IgE antibodies for food allergens, leading to desensitization to oral antigens in the gut (Fig.3) 


Fig.3 The process of IgE-mediated allergy and desensitization to oral antigens in the gut.

Food allergy: immune mechanisms, diagnosis and immunotherapy. Yu et al. Nature Reviews Immunology 16, 751–765(2016).